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One branch is responsible for the synthesis of -carotene and its derivatives by lycopene epsilon cyclase (LCY) and lycopene beta cyclase (LCY)

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[DOI] [PubMed] [Google Scholar] Lavickova B

In addition peroxidase induces oxidative stress and changes in the NAD(+)/NADH redox state, leading to the release of cytochrome C from the mitochondria, dysregulation of the expression of Sirtuins and HIF-1, and ultimately retinal pigment epithelial (RPE) cell death